The AQP4-Abs are known to be highly specific biomarkers for NMO, but some studies have also found antibodies against myelin oligodendrocyte glycoprotein (MOG-Abs) in clinically defined AQP4 negative NMO/NMOSD patients. Īntibodies against native MOG are present in 20-40% of children with ADEM or MS. The MOG-Abs are detected in variable proportions of patients with different CNS diseases such as bilateral ON, Neuromyelitis Optica (NMO)/Neuromyelitis Optica Spectrum Disorder (NMOSD), multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), and anti-NMDA-receptor (NMDAR)-antibody-associated encephalitis. Neuro-Ophthalmology, Myelin oligodendrocyte glycoprotein (MOG), Neuromyelitis optica, Optic Neuritis, Multiple sclerosis This may have implications for treatment and prognosis of these patients. The clinical implications of MOG-Abs are not yet clear, but MOG-Abs may detect a subclass of otherwise idiopathic ON patients negative for AQP4 Abs. Conventional cell-based immunoassays revealed that she was seropositive for MOG-Abs and seronegative for AQP4-Abs. The patient was treated with a course of high-dose methylprednisolone. The patient did not fulfil the diagnostic criteria for the above-mentioned diseases. Magnetic resonance (contrast enhanced) revealed a thickened right optic nerve and a T2-hyperintense lesion in the periventricular white matter. We present a case report of a 15-year-old Caucasian schoolgirl thoroughly examined with a single episode of right-sided Optic Neuritis (ON) who tested positive for MOG-Abs. ![]() The role of MOG-Abs in the clinical setting is unclear. The MOG-antibodies (Abs) are detected in variable proportions of patients with different diseases such as Multiple Sclerosis (MS), Neuromyelitis Optica/Neuromyelitis Optica Spectrum Disorder, bilateral optic neuritis, acute disseminated encephalomyelitis and anti-NMDA-receptor-antibody-associated encephalitis. The myelin oligodendrocyte glycoprotein (MOG) is a membrane protein expressed on the outmost surface of the myelin sheath in the central nervous system (CNS). Anti-Myelin Oligodendrocyte Glycoprotein (MOG) in a Patient with Optic Neuritis
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |